2 The ACMP has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. 1 Its prevalence was approximately 2–3% in the infant population. The prevalence of allergy to cow's milk proteins (ACMP) increases significantly it affects 0.5–6% of the infant population. These results have for the first time provided evidence that pre-treatment with taurine appears to prevent intestinal damage induced by β-Lg. Treatment with taurine significantly decreased the IgG ( p < 0.001) and IgE anti β-Lg levels ( p < 0.05). No statistically significant difference in the serum levels of TNF-α or IL-6 was found after oral or intraperitoneal administration of taurine. Histological and morphometric analysis showed that taurine reduced the intestinal damage and limited intestine retraction caused by β-Lg sensitization. ResultsĬompared with sensitized mice, β-Lg challenge of intestinal epithelium of taurine-pre-treated mice in Ussing chamber did not influence the intensity of Isc, nor produce any changes in the G, reflecting a reduction in the secretory response and epithelial permeability. Serum IgG and IgE anti-β-Lg were determined by ELISA. Serum levels of TNF-α and IL-6 were measured. Histological study was used to assess gut inflammation. The electrophysiological parameters: active ion transport of chloride (Short-circuit current: Isc) and the passive ion permeability (Conductance: G) were measured ex vivo in Ussing chamber by intestine challenge with β-Lg. Methodsīalb/c mice were treated with taurine administered orally by gavage (3 mmol/kg/day) or intraperitoneally (100 mg/kg/day) for two weeks, then sensitized intraperitoneally with β-Lg. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (β-Lg) in Balb/c mice used as an animal model of allergy to cow's milk proteins. See moreĪllergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. Letters to the Editor on previously published papers are welcomed.Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View"
The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology. Manuscripts related to clinical, epidemiological and experimental allergology and childhood immunopathology will be considered for publication. Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon PublicationsĪllergologia et Immunopathologia is a forum for those working in the field of asthma, allergy and immunology related to childhood.
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